Tumor Vascular Microenvironment of Colorectal Hepatic Metastasis and Chemotherapy Response

Background: The tumor vascular microenvironment has an important role in progression and metastasis. objective of this study was to assess the significance metastatic hepatic relation response systemic fluorouracil-based chemotherapy [folinic acid/fluorouracil/oxaliplatin (FOLFOX) or folinic acid/fluorouracil/irinotecan (FOLFIRI)]. Patients Methods: A total 48 consecutive patients with colorectal cancer (CRC) metastasis were retrospectively reviewed, factors such as microenvironment, resection, analyzed. Tumor angiogenesis microscopically evaluated by microvessel density (MVD) sections stained immunochemically antibody CD34 resection. Angiogenesis association ring enhancement (RE) on computed tomography (CT) also examined. Results: Microscopic examination revealed that peripheral RE CT associated MVD. overall rate after six courses first-line for liver 64% (23/36), whereas those without 25% (3/12), which significantly lower, although survival RE-positive RE-negative tumors did not differ significantly. Conclusion: Peripheral higher response.